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A previous in vitro study demonstrated that 7-day exposure of motor neurons to fluvastatin has less effects on spinal motor neurons in a dose-dependent manner (Murinson et al., 2012)

A double-blind, placebo-controlled trial in 90 HIV-positive patients with symptomatic distal symmetrical polyneuropathy found no benefit of intramuscular injection with 1 g/day of ALCAR for two weeks in the intention-to-treat analysis, but there was some pain relief in the group of 66 patients who completed the trial (84)

Indeed, L-citrulline is known to exert positive effects on exercise performance and recovery (Gonzalez and Trexler 2020)

doi: 10.3389/fmed.2021.689042 Received 31 March 2021 Accepted 15 June 2021 Published 09 August 2021 Volume 8 - 2021 Edited by Oscar Escribano, Complutense University of Madrid, Spain Reviewed by Adriaan Holleboom, Academic Medical Center, Netherlands